PDF Download Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)By Scott D. Patterson, Byron Jones

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Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)By Scott D. Patterson, Byron Jones

PDF Download Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)By Scott D. Patterson, Byron Jones

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Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology explores statistics used in day-to-day clinical pharmacology work. The book covers the methods needed to design, analyze, and interpret bioequivalence trials; explores when, how, and why these studies are performed as part of drug development; and demonstrates the proposed methods using real world examples.

Drawing on knowledge gained directly from working in the pharmaceutical industry, the authors set the stage by describing the general role of statistics. Once the foundation of clinical pharmacology drug development, regulatory applications, and the design and analysis of bioequivalence trials are established, they move on to related topics in clinical pharmacology involving the use of cross-over designs. These include, but are not limited to, safety studies in Phase I, dose-response trials, drug interaction trials, food-effect and combination trials, QTc and other pharmacodynamic equivalence trials, and dose-proportionality trials. Purposefully designed to be instantly applicable, the book provides examples of SAS code so that the analysis described can be immediately implemented. The authors have made extensive use of the proc mixed procedures available in SAS.

Each chapter includes a vignette based on co-author Scott Patterson's experience in the clinical pharmacology work place and all the data sets are taken from real trials. The authors delineate practical utility and objectives, provide real-world examples of the topic under discussion, and include statistical theory and applications. Technical theory, where extensive, is included in technical appendices at the end of the chapter. Each topic contains worked examples that illustrate the applications of the statistical techniques and their interpretation. The authors also develop statistical tools useful for other topics of clinical pharmacology - namely general safety testing, testing for proarrythmic potential, population pharmacokinetics, and dose-selection.

• Sales Rank: #2906059 in eBooks
• Published on: 2005-11-10
• Released on: 2005-11-10
• Format: Kindle eBook

Review
I really enjoyed reading this book. Each chapter includes an excellent introduction based on Scott Patterson's experience working as a biometrician. This will especially be of interest to young statisticians starting their career in the pharmaceutical industry. Therefore, I strongly recommend this book to all pharmaceutical statisticians to learn more of the challenging statistical problems being generated in drug development. In addition, the presented material provides a springboard for all scientists from academia who are looking to do research in this area of medical applications.
- Dieter Haushcke, writing in Biometrics, September, 2006

The authors formulate bioequivalence exhaustively and clearly. …Given the background of the authors, they constitute a key piece of social information in understanding the context in which clinical pharmacology research develops within the pharmaceutical industry.
-Journal of Biopharmaceutical Statistics

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Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)By Scott D. Patterson, Byron Jones PDF

Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series)By Scott D. Patterson, Byron Jones PDF

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• Published on: 1702
• Binding: Paperback

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Now in paperback, this book provides an overview of the physics of condensed matter systems. Assuming a familiarity with the basics of quantum mechanics and statistical mechanics, the book establishes a general framework for describing condensed phases of matter based on symmetries and conservation laws. After surveying the structure and properties of materials with different symmetries, it explores the role of spatial dimensionality and microscopic interactions in determining the nature of phase transitions. Particular attention is given to critical phenomena and renormalization group methods. The properties of liquids, liquid crystals, quasicrystals, crystalline solids, magnetically ordered systems and amorphous solids are investigated in terms of their symmetry, generalized rigidity, hydrodynamics and topological defect structure. In addition to serving as a course text, this book is an essential reference for students and researchers in physics, applied physics, chemistry, materials science and engineering, who are interested in modern condensed matter physics.

• Sales Rank: #822154 in Books
• Brand: Brand: Cambridge University Press
• Published on: 2000-10-09
• Released on: 2000-09-28
• Original language: English
• Number of items: 1
• Dimensions: 9.72" h x 1.46" w x 6.85" l, 2.85 pounds
• Binding: Paperback
• 720 pages

Features

• Used Book in Good Condition

Review
"...an important achievement...it will strengthen the understanding by students and researchers for a long time to come." Physics Today

"...an important achievement...among the book's pedagogical features are a wealth of daunting problems, a pithy glossary of intimidating terms and concrete descriptions of experiments and technological applications...it will strengthen the understanding by students and researchers for a long time to come." Physics Today

"...an excellent introduction to the processes by which atoms and molecules become materials and how materials acquire their properties. It is beautifully organized to form the basis of a lecture course." Science

"The present book is especially welcome at a time when we are witnessing vigorous activity in all fields concerned with ^soft matter....It contains a thorough and detailed treatment of all the subjects and is intended also to be suitable as a reference text for active researchers....This book presents a most fortunate blend of theoretical depth and encyclopedic grasp of phenomenology, while being written in a pedagogically sound and elegant manner....this monograph is a well-written, thorough, modern book on soft condensed matter physics that I wholeheartedly recommend to everybody with an interest in this subject." Rudolf Podgornik, Journal of Statistical Physics

"For the interested researcher, the self-contained chapters provide succint overviews of the topics and more than enough information for going it alone into this exciting and evolving field." Science

"The classic textbook for soft condensed matter..." Physics Today

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